Clinical Laboratory Science (under its former name of Medical Technology) appeared in Corpus Christi in 1959 as a hospital-based program offered by Spohn Hospital. The Council on Medical Education of the American Medical Association (AMA) initially approved an enrollment of four students in this program.
In 1974, the program became part of the new Texas A&I University-Corpus Christi, and the Council on Medical Education of the AMA approved increasing its enrollment to twelve students. At this time, the program also began to expand its clinical affiliate base beyond Spohn Hospital. The program has persisted through several changes in the institution's name: Texas A&I University-Corpus Christi (1973-1977), Corpus Christi State University (1977-1993) and Texas A&M University-Corpus Christi (1993-present).
In 1990, the Clinical Laboratory Science Program developed an associate-to-baccalaureate articulation curriculum that is a model for the state of Texas. This curriculum allows for the timely completion of coursework and certification requirements (even for part-time students) by offering Level I courses during the Fall Semester, Level II courses during the Spring Semester, and Clinical Experiences during the Summer Semester. By 1991, the program had affiliations with ten clinical facilities located throughout the Coastal Bend region of South Texas.
In 2003, Pre-Clinical Laboratory Science became an option in the Biomedical Sciences (BIMS) Program. Pre-Clinical Laboratory Science students completed the courses required for the Bachelor of Science in Biomedical Sciences in the Spring Semester (and can graduate in May). The title of this option included "Pre-" because the clinical experiences required for CLS certification were offered in the Summer Semester after the students had graduated (post-baccalaureate). Students from other majors and options in the BIMS Program could take some of the traditional Clinical Laboratory Science courses. Interdisciplinary associations between Clinical Laboratory Science and other areas have been responsible for the development of the new Forensic Science Option in the BIMS Program.
In 2006, the College of Science and Technology was reorganized. Following a decade of phenomenal growth, the large Department of Physical and Life Sciences was divided into two smaller departments. The Biomedical Sciences Program became part of the new Department of Life Sciences. This reorganization gave the programs greater flexibility to respond quickly to the needs of the academic and regional community. It also underscores the College's commitment to quality teaching and research (both basic and clinical) to develop and maintain a high standard of health-care in the Coastal Bend.
In 2018, the Clinical Laboratory Science program was separated from Biomedical Sciences primarily due to strong enrollment and is offered now as a bachelor of science degree in Clinical Laboratory Science or a post-bac certification.