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Protein Folding and Shape
"Pipe Cleaner, Perms, and Mad Cows"



Objectives of this Course Component: The students are expected to understand the four levels of protein structure, construct models that simulate protein folding, evaluate the accuracy of such models, understand why protein shape is critical to the induced fit model of enzyme action, apply these concepts to differing proteins, and relate how these concepts are relevant to their lives.
Overall Time Frame: Approximately one, 50-minute class, plus 10-20 minutes in the following class.
Prior Knowledge: Assigned readings on basic protein structure and enzyme function, short lecture covering this information, or both. The Course Component may work best if the students are familiar with amino acids, peptide bonds, proteins, hydrogen bonding, and enzyme actions.


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This Course Component in PDF

I. Introduction
II. Activities
Inquiry A: Pipe Cleaner Proteins
Inquiry B: Perms
Inquiry C: Poisons
III. Assessment & Evaluation
IV. Appendix of Resources
Article from the New-York Times

Download the Whole Course Component: Protein Folding and Shape (30 KB)


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